Publications by authors named "J P Kirwan"
Analytical technologies and methods play a pivotal role in attribute understanding and control which are essential to the rapidly evolving field of pharmaceutical development and manufacturing. These technologies are advancing quickly, where innovations often involve both new scientific approaches and novel applications of established techniques. In many cases, the lack of harmonized global regulatory expectations presents challenges for the adoption of advanced technologies.
View Article and Find Full Text PDFMetabolomics and lipidomics are pivotal in understanding phenotypic variations beyond genomics. However, quantification and comparability of mass spectrometry (MS)-derived data are challenging. Standardised assays can enhance data comparability, enabling applications in multi-center epidemiological and clinical studies.
View Article and Find Full Text PDFObjective: Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are effective procedures to treat and manage type 2 diabetes (T2D). However, the underlying metabolic adaptations that mediate improvements in glucose homeostasis remain largely elusive. The purpose of this study was to identify metabolic signatures associated with biochemical resolution of T2D after medical therapy (MT) or bariatric surgery.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates sex differences in podocyte cells, which are key for kidney function, particularly how these differences manifest under normal and stressed conditions caused by mTOR inhibition.
- Using a specialized mouse model, researchers isolated podocytes and performed RNA sequencing, proteomics, and metabolomics to uncover distinct molecular signatures tied to biological sex.
- Results showed significant sex-specific variations in gene expression and protein levels, with mTOR inhibition affecting male podocyte responses more prominently, highlighting potential transcription factors that govern these differences.