Publications by authors named "J P Kirkness"
Innovative advancements in preclinical imaging have led to the development of cone-beam computed tomography (CBCT) combined with contrast-free pulmonary angiography (CFPA), a novel lung scanning technology capable of assessing lung function and pulmonary vascular morphology. This cutting-edge approach integrates CBCT to provide detailed quantification of the pulmonary vascular tree. The application of this technique to image and quantify changes in the pulmonary vascular tree of mice exposed to chronic hypoxia has not been investigated.
View Article and Find Full Text PDFThe U.S. Sergeant First Class Heath Robinson Honoring our Promise to Address Comprehensive Toxics (PACT) Act expands benefits and services to U.
View Article and Find Full Text PDFArticle Synopsis
- U.S. troops deployed to the Middle East were exposed to toxic airborne hazards and burn pits, which release harmful emissions containing particulate matter, toxic gases, and heavy metals.
- Ongoing research shows these exposures can lead to significant and lasting health issues, particularly concerning lung health, though data on long-term consequences is still limited.
- The 2022 PACT Act aims to enhance benefits for affected Veterans, mandates toxic exposure screenings, and promotes further research and education on the health impacts of these toxic exposures.
Rationale: X-ray velocimetry (XV) has been utilized in preclinical models to assess lung motion and regional ventilation, though no studies have compared XV-derived physiologic parameters to measures derived through conventional means.
Objectives: To assess agreement between XV-analysis of fluoroscopic lung images and pitot tube flowmeter measures of ventilation.
Methods: XV- and pitot tube-derived ventilatory parameters were compared during tidal breathing and with bilevel-assisted breathing.
Introduction: X-ray Velocimetry (XV) ventilation analysis is a 4-dimensional imaging-based method for quantifying regional ventilation, aiding in the assessment of lung function. We examined the performance characteristics of XV ventilation analysis by examining correlation to spirometry and measurement repeatability.
Methods: XV analysis was assessed in 27 patients receiving thoracic radiotherapy for non-lung cancer malignancies.