Publications by authors named "J P Kalala"
Changes in serum concentration of perioperative inflammatory cytokines following the timing of surgery among mild-moderate traumatic brain injury patients and factors associated.
Front Neurol
December 2024
Article Synopsis
- The study investigates the optimal timing for surgery after traumatic brain injury (TBI) and its effect on inflammatory cytokine levels.
- It involved 82 TBI patients with depressed skull fractures, analyzing pre-and postoperative serum samples using a specialized assay to measure cytokine levels.
- Results indicated that surgeries performed after 48 hours post-injury were associated with significantly higher TNF-α levels, while factors like post-traumatic seizures and neurological deficits influenced cytokine responses.
Timing of Surgery and Preoperative Predictors of Surgical Site Infections for Patients with Depressed Skull Fractures in a Sub-Saharan Tertiary Hospital: A Prospective Cohort Study.
Neurotrauma Rep
September 2024
Article Synopsis
- Surgical site infections (SSIs) are a significant risk for patients undergoing surgery for depressed skull fractures, especially when the surgery occurs more than 48 hours post-injury.
- A study at Mulago Hospital in Uganda, involving 127 patients, found a higher incidence of SSIs (57.3%) when surgery was delayed beyond 48 hours compared to those operated on sooner (42.7%).
- Key predictors of increased SSI risk include the fracture's location (frontal), the presence of air in the cranial cavity on CT scans, and prolonged hospital stays, emphasizing the need for timely surgical intervention.
Metagenomic sequencing of the skin microbiota of the scalp predicting the risk of surgical site infections following surgery of traumatic brain injury in sub-Saharan Africa.
PLoS One
July 2024
Background: Surgical site infections (SSI) are a significant concern following traumatic brain injury (TBI) surgery and often stem from the skin's microbiota near the surgical site, allowing bacteria to penetrate deeper layers and potentially causing severe infections in the cranial cavity. This study investigated the relationship between scalp skin microbiota composition and the risk of SSI after TBI surgery in sub-Saharan Africa (SSA).
Methods: This was a prospective cohort study, enrolling patients scheduled for TBI surgery.
A female survival benefit has been described for glioblastoma patients. Recent studies report that the effect of 0-methylguanine-DNA-methyltransferase gene promoter (MGMTp) methylation is only present in female patients. We retrospectively studied sex-based survival, including MGMTp-methylation, in a cohort of 159 uniformly treated isocitrate dehydrogenase wildtype (IDHwt) patients.
View Article and Find Full Text PDFThe supplementary motor area (SMA) syndrome is a frequently encountered clinical phenomenon associated with surgery of the dorsomedial prefrontal lobe. The region has a known motor sequencing function and the dominant pre-SMA specifically is associated with more complex language functions; the SMA is furthermore incorporated in the negative motor network. The SMA has a rich interconnectivity with other cortical regions and subcortical structures using the frontal aslant tract (FAT) and the frontostriatal tract (FST).
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