Publications by authors named "J P KEENAN"
Purpose: To investigate the association between rim area focal hyperautofluorescence (RAFH) signals and geographic atrophy (GA) growth rates, as well as the impact of oral metformin on the longitudinal change of RAFH.
Design: Secondary analysis of a randomized controlled trial.
Participants: Seventy-one eyes from 44 participants with GA and ≥6 months of follow-up in the METformin for the MINimization of geographic atrophy progression study.
Objective: To describe electroencephalographic (EEG) changes in pediatric patients with cerebral edema after cardiac arrest.
Methods: A retrospective study of patients admitted to the pediatric intensive care unit from July 2021 to January 2023. We included patients with cardiac arrest and changes in EEG background with clinical changes and/or neuroimaging consistent with cerebral edema.
Objective: Randomized data support transplantation of hearts from donors after circulatory death. This may lead to a sizeable increase in the donor pool. Regional variations in donors after circulatory death heart use were examined to help elucidate barriers to donor pool expansion.
View Article and Find Full Text PDFAssociation between Systemic Methotrexate Therapy and Proliferative Vitreoretinopathy.
Ophthalmol Retina
November 2024
Article Synopsis
- The study aimed to evaluate whether patients on systemic methotrexate therapy had a lower rate of developing proliferative vitreoretinopathy (PVR) after retinal detachment (RD) surgery.
- Researchers used a multicenter retrospective cohort design, analyzing data from patients aged 18 and older who had RD surgery between 2004 and 2024 and met specific inclusion criteria.
- Results showed that patients taking methotrexate had a significantly lower cumulative incidence of PVR (4.2%) within 6 months post-surgery compared to those not on methotrexate (9.2%), suggesting that methotrexate may be protective against PVR.