Growth and metabolic performance of house fly and black soldier fly larvae differ across densities and waste-based growth substrates.

Large scale production of insect larvae is considered a sustainable way to upcycle various organic waste- and by-products into more valuable food and feed products. The sustainability of insect larvae production depends on the substrates and species being used, but comparative studies that include both growth and efficiency are lacking. Here we compare larval fitness, including survival, development time, weight, substrate conversion efficiency, substrate reduction, and metabolic parameters across different combinations of densities and waste- and by-product-based substrates on the two fly species, the house fly (Musca domestica) and the black soldier fly (Hermetia illucens).

Range-scalable distributed acoustic sensing with EDFA repeaters demonstrated over 2227 km.

We demonstrate a new, to the best of our knowledge, range-scalable repeatered distributed acoustic sensing (DAS) solution sharing technology with existing long-haul subsea telecom networks capable of low noise and high spatial and temporal resolution. Single ended DAS interrogation through a 2227 km line comprising 39 repeatered fiber spans is demonstrated with a 10 m spatial resolution, a 1.78 kHz sampling rate, and a strain resolution of 35 pε/√Hz for the outermost span.

Efficient reinterpretation of rare disease cases using Exomiser.

Whole genome sequencing has transformed rare disease research; however, 50-80% of rare disease patients remain undiagnosed after such testing. Regular reanalysis can identify new diagnoses, especially in newly discovered disease-gene associations, but efficient tools are required to support clinical interpretation. Exomiser, a phenotype-driven variant prioritisation tool, fulfils this role; within the 100,000 Genomes Project (100kGP), diagnoses were identified after reanalysis in 463 (2%) of 24,015 unsolved patients after previous analysis for variants in known disease genes.

Enhancing Buccal Drug Delivery: The Impact of Glycerol in Slot-Die-Coated Pectin Films.

Buccal delivery offers a promising alternative to e.g., oral or parenteral drug administrations by leveraging the mucosal membranes of the mouth to enhance drug absorption and enhance patient compliance.

Attitudes Toward Medical Assistance in Dying Among Swedish Palliative Care Professionals.

The debate over legalizing medical assistance in dying (assisted dying) is ongoing, also in Nordic countries such as Sweden where assisted dying is illegal. A 2020 survey by the Swedish Medical Association highlighted varied perspectives, with 41% of physicians supporting and 34% opposing legalization. Professionals in palliative care were more negative toward it.