An effective algaecide for the targeted destruction of Karenia brevis.

We address the targeted destruction of Karenia brevis using the algaecide calcium peroxide, in tandem with the flocculation and sinking of the species. The specific aspect of the approach is the incorporation of the algaecide within the floc to rapidly kill K. brevis, thus minimizing escape of cells from the floc and reentry to the water column.

EASE LID 2: A 2-Year Open-Label Trial of Gocovri (Amantadine) Extended Release for Dyskinesia in Parkinson's Disease.

Background: Gocovri® (amantadine) extended release capsules are approved for the treatment of dyskinesia in patients with Parkinson's disease (PD) receiving levodopa-based therapy.

Objective: To evaluate the long-term safety, tolerability, and efficacy of Gocovri in patients with PD experiencing levodopa-induced dyskinesia.

Methods: In this 2-year open-label trial, patients completing double-blind Gocovri clinical trials or excluded from prior trials because of deep-brain stimulation (DBS) received Gocovri 274 mg once daily at bedtime.

analyses of the edaravone clinical trials Study 16 and Study 19: a step toward more efficient clinical trial designs in amyotrophic lateral sclerosis.

The edaravone development program established a study design in which a treatment effect slowing functional loss in amyotrophic lateral sclerosis (ALS) could be documented within a 24-week time frame. This report elucidates the strategic enrichment design utilized to create efficiency and precision in the development program. analyses describe learning, sequential iteration, and evolution in study design.

Scapular muscle balance and spinal stabilizer recruitment during an inverted row.

Persons with subacromial impingement syndrome (SIS) have an imbalance in scapular muscle recruitment. To avoid humeral head compression against the coracoacromial arch during the early stages of rehabilitation, physical therapists recommend movements targeting scapular retraction, shoulder depression, and arm extension such as the inverted row (IR) exercise. The purposes of this study were to describe: (1) scapular balance ratios during an IR and (2) the magnitudes of recruitment of spinal stabilizer muscles.

Apomorphine Subcutaneous Injection for the Management of Morning Akinesia in Parkinson's Disease.

Background: In patients with motor fluctuations complicating Parkinson's disease (PD), delays in time-to-ON with levodopa are common. This open-label study aimed to assess the effect of apomorphine on time-to-ON in PD patients with morning akinesia.

Methods: The safety population included 127 enrolled patients, and the full analysis set (FAS) included 88 patients.