Publications by authors named "J P Houde"
Article Synopsis
- Traditional Diffusion Tensor Imaging (DTI) approaches struggle with issues like crossing fibers and lesions, which limit the accuracy of tractography results.
- A new tractometry pipeline introduces multi-tensor fixel-based metrics, utilizing a robust method called Multi-Resolution Discrete Search (MRDS) to improve sensitivity and noise resistance.
- Evaluation results show that this method excels in detecting white matter anomalies in patients with conditions like multiple sclerosis, outperforming traditional single-tensor methods.
Background: Mycobacterial culture is routinely performed to diagnose tuberculosis (TB) in Canada. Globally, meta-analyses suggest that up to 2% of positive cultures are falsely positive for due to laboratory cross-contamination. Five patients from distinct clinical institutions in Montréal were diagnosed with culture-positive TB as their clinical samples were processed in a centralized mycobacteria laboratory.
View Article and Find Full Text PDFBased on historic observations that children with reading disabilities were disproportionately both male and non-right-handed, and that early life insults of the left hemisphere were more frequent in boys and non-right-handed children, it was proposed that early focal neuronal injury disrupts typical patterns of motor hand and language dominance and in the process produces developmental dyslexia. To date, these theories remain controversial. We revisited these earliest theories in a contemporary manner, investigating demographics associated with reading disability, and in a subgroup with and without reading disability, compared structural imaging as well as patterns of activity during tasks of verb generation and non-word repetition using magnetoencephalography source imaging.
View Article and Find Full Text PDFA successful efference copy self-prediction suppresses auditory signals in the primary auditory cortex (A1) is necessary for speakers to successfully compare auditory feedback during speech production with auditory feedback during passive listening, this is called speaker-induced suppression (SIS). The top-rank positive symptom in schizophrenic (SZ) patients, auditory verbal hallucination, for instance, is hypothesized to relate to failure to distinguish the internal voice and external sounds, and this deficit is thought to be associated with impaired self-prediction in comparing external and self-generated contents. In this magnetoencephalographic imaging (MEGI) study, we compared SIS M100 in the primary auditory cortex (A1) between the healthy controls (HC; N = 30) and SZ patients (N = 22).
View Article and Find Full Text PDFArticle Synopsis
- Behavioral speech tasks help analyze speech control in both typical speakers and clinical groups, but it's tough to pinpoint specific neural differences just from behavioral data since multiple factors can cause similar effects.
- This study applied computational modeling, specifically Bayesian inference, to compare the pitch control responses between individuals with cerebellar ataxia (CA) and typical speakers, revealing that CA speakers have a different weighting of auditory and sensory feedback and greater responsiveness to errors.
- The findings provide insights into how CA impacts speech motor control and demonstrate the effectiveness of using Bayesian modeling to better understand complex speech behavior patterns for future research.