Publications by authors named "J P Holm"
Background: Lipid species are emerging as biomarkers for cardiometabolic risk in both adults and children. The genetic regulation of lipid species and their impact on cardiometabolic risk during early life remain unexplored.
Methods: Using mass spectrometry-based lipidomics, we measured 227 plasma lipid species in 1149 children and adolescents (44.
Article Synopsis
- Insulin resistance is a crucial factor in developing cardiometabolic diseases, and while genetic risk scores for it have been validated in adults, their applicability to youth is uncertain.
- A study involving children and adolescents with and without obesity evaluated adult-derived genetic risk scores (GRSs) for insulin resistance, showing significant associations with various cardiometabolic traits.
- The findings indicate that these GRSs could help assess insulin resistance-related cardiometabolic risk in youth if further validated in future studies.
Introduction: Childhood-onset obesity poses significant health risks, including early-onset type 2 diabetes, cardiovascular disease, and reduced quality of life. Hospital-based non-pharmacological obesity care can reduce childhood obesity, but 25% of children do not respond. Therefore, this study investigates the effect of the glucagon-like peptide-1 receptor agonist, semaglutide, as an add-on to hospital-based obesity care in youth who still have obesity following hospital-based obesity care as children.
View Article and Find Full Text PDFThe microbiota in individual habitats differ in both relative composition and absolute abundance. While sequencing approaches determine the relative abundances of taxa and genes, they do not provide information on their absolute abundances. Here, we developed a machine-learning approach to predict fecal microbial loads (microbial cells per gram) solely from relative abundance data.
View Article and Find Full Text PDFArticle Synopsis
- * A systematic review and meta-analysis will be conducted following established guidelines, incorporating diverse databases to gather relevant studies and evaluate pain intensity and related outcomes.
- * The findings are expected to clarify the effectiveness of different analgesia methods, assisting in future decisions about pain management strategies for VATS patients.