Publications by authors named "J P Haran"
Background: Chronic pain following traumatic stress exposure (TSE) is common. Increasing evidence suggests inflammatory/immune mechanisms are induced by TSE, play a key role in the recovery process versus development of post-TSE chronic pain, and are sex specific. In this study, we tested the hypothesis that the inflammatory marker C-reactive protein (CRP) is associated with chronic pain after TSE in a sex-specific manner.
View Article and Find Full Text PDFSocial Buffering of PTSD: Longitudinal Effects and Neural Mediators.
Biol Psychiatry Cogn Neurosci Neuroimaging
November 2024
Article Synopsis
- This study investigates how early social support after trauma affects PTSD symptoms over time and explores specific brain regions involved in this process, such as the amygdala and ventromedial prefrontal cortex.
- Using data from 315 participants in the AURORA study, researchers measured PTSD symptoms and perceived emotional support at multiple time points, while also conducting neuroimaging two weeks post-trauma.
- The results show that early emotional support is linked to changes in white matter connectivity between key brain areas, but it also highlighted unexpected increased threat reactivity in the default mode network, suggesting complex neural pathways in response to social threats.
Introduction: There is a lack of cognitive tools to predict disease progression in mild cognitive impairment (MCI) and Alzheimer's disease (AD).
Methods: We assessed patients with MCI, AD, and cognitively healthy controls (cHC) using NIH toolbox assessments for attention/concentration and executive functioning and overall cognitive decline by the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog).
Results: Among 183 participants over a median follow-up of 540 days, both between- and within-subjects variance in NIH toolbox and ADAS-Cog assessments increased from cHC to MCI to AD patients.
Article Synopsis
- - The study explored the use of wrist-wearable devices to track heart rate variability (HRV) as potential biomarkers for recovery from adverse neuropsychiatric effects following traumatic events, specifically in a socioeconomically disadvantaged group.
- - Researchers monitored participants within 72 hours of a traumatic event and over a course of 6 months, validating HRV characteristics linked to various posttraumatic symptoms, such as pain, re-experiencing, and anxiety.
- - The findings indicate that changes in HRV could effectively predict improvements or worsening in symptoms, suggesting that these wearable technologies could serve as useful screening tools for identifying posttraumatic stress in high-risk populations.
Article Synopsis
- - The study investigates sex/gender differences in PTSD by examining 16 risk factors and their impact on PTSD severity in a group of 2,924 acutely traumatized individuals.
- - It finds that six risk factors are more prevalent in women, while none are more pronounced in men, highlighting unique pathways contributing to PTSD severity based on sex assigned at birth.
- - The results indicate different risk mechanisms for men and women, suggesting that understanding these differences can help develop targeted mental health interventions and inform future research on other mental disorders.