Evaluation of particle translocation across the alveolo-capillary barrier in isolated perfused rabbit lung model.

Particulate air pollution is associated with respiratory and cardiovascular morbidity and mortality. It has been suggested that ultrafine particles are able to translocate from the airways into the bloodstream in vivo. We have investigated this in an isolated perfused and ventilated rabbit lung preparation lacking pulmonary lymphatic flow.

Effect of polystyrene particles on lung microvascular permeability in isolated perfused rabbit lungs: role of size and surface properties.

The aim of this study was to investigate the role of particle number, total surface area, mass and surface chemical groups in (K(f,c)) changes. The lung effects of four different fine (110 nm) and ultrafine (24 nm) polystyrene particles have been tested in an isolated perfused rabbit lung model. Pulmonary microvascular permeability (K(f,c)) modifications were measured in response to intratracheal particle challenge.

Differential diagnosis of neurologically expressed disorders in Western European cattle.

A classification of neurological or neurologically expressed disorders that occur in Western European cattle aged 12 month and over has been established on the basis of aetiology, frequency and conditions of appearance, age and type of animals concerned and the main clinical signs observed. Neurologically expressed disorders have been classified according to different groups of causes: biological, non-biological and non-specific or unknown. Differential diagnosis of neurologically expressed disorders is an essential element in the clinical epidemiological surveillance of bovine spongiform encephalopathy.