Publications by authors named "J P Gardella"
In Brief: Clinical drug trials often do not include pregnant people due to health risks; therefore, many medications have an unknown effect on the developing fetus. Machine learning QSAR models have been used successfully to predict the fetal risk of pharmaceutical use during pregnancy.
Abstract: Those undergoing pregnancy are often excluded from clinical drug trials due to the risk that participation would pose to their health and the health of the developing fetus.
Approximately 50% of U.S. students attend a school with a school officer.
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- The study aimed to compare how well the Modified Frailty Index and the Modified Surgical Apgar scores predict postoperative outcomes, specifically complications and mortality, in head and neck cancer patients.
- The analysis involved 723 patients who underwent major surgeries from 2012 to 2015, with results showing that both scoring systems were significantly linked to 30-day complications, but the Modified Surgical Apgar score was more effective.
- Ultimately, while both scores are valuable for assessing patient risk, the Modified Surgical Apgar score provided better predictive power, and using them together did not enhance accuracy significantly.
Article Synopsis
- The study examines how the source of referral (dental vs. medical specialty) affects the stage of oral cavity squamous cell carcinoma (OSCC) when patients first present for treatment, emphasizing the importance of timely diagnosis.
- Conducted at Roswell Park Comprehensive Cancer Center, it analyzed data from 215 patients diagnosed between 2014 and 2023, finding that those referred by dental providers presented with earlier disease stages compared to those referred by medical specialties.
- The results indicated that early dental referrals significantly improved patient outcomes, with a noted increase in the likelihood of presenting at a less advanced T stage and lower rates of cervical nodal involvement.
Skyrocketing pollution: assessing the environmental fate of July 4th fireworks in New York City.
J Expo Sci Environ Epidemiol
August 2024
Background: Pyrotechnic displays often lead to significant increases in poor air quality. The widespread environmental fate-involving air, water, and spatial-temporal analyses-of fireworks-produced pollutants has seldom been investigated.
Objective: This study examined the environmental fate of pollutants from the largest fireworks event in the U.