Publications by authors named "J P Gangneux"
Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) is a life-threatening complication in patients with severe COVID-19. Previously, acute respiratory distress syndrome in patients with COVID-19 has been associated with lung fungal dysbiosis, evidenced by reduced microbial diversity and colonization. Increased fungal burden in the lungs of critically ill COVID-19 patients is linked to prolonged mechanical ventilation and increased mortality.
View Article and Find Full Text PDFThis study investigates the diagnostic practices for mucormycosis among 30 French University Hospital mycology laboratories, in 2024. All laboratories perform both direct examination and culture, with fluorescent brighteners being the most commonly used method for direct examination. While 77 % of the participating laboratories routinely identify Mucorales to the species level, with 70 % having adopted Mucorales-specific quantitative PCR, primarily for the diagnosis of invasive fungal infections.
View Article and Find Full Text PDFArticle Synopsis
- Siderophores are iron-scavenging compounds secreted by certain fungal strains during their growth, playing a role in their virulence and potential use as clinical biomarkers for invasive infections like scedosporiosis and lomentosporiosis.
- The strains produced various types of siderophores, with -methyl-coprogen B being the most abundant and secreted faster, particularly under conditions of limited iron and zinc, which may increase their virulence.
- Additionally, two new cyclic peptides were identified using advanced sequencing, and the detection methods for coprogens were refined, suggesting they could be valuable tools for diagnosing these infections in clinical settings.
Objectives: Allergic bronchopulmonary aspergillosis (ABPA) is a complex lung disease associated with significant morbidity. The ABPA Working Group (AWG) of the International Society for Human and Animal Mycology (ISHAM) revised their management guidelines in 2024, but there is currently no standardised tool to assess adherence to these recommendations.
Methods: We extracted key recommendations from the updated 2024 ISHAM-AWG guidelines, focusing on critical areas: screening and diagnosis of ABPA, managing acute and treatment-dependent ABPA, and monitoring treatment response.