Publications by authors named "J P Fournier"
Obstructive sleep apnoea (OSA) contributes to cerebrovascular diseases and cognitive decline. Preclinical studies support the deleterious impact on the brain of intermittent hypoxia (IH), one of the main components of OSA, but heterogeneity in rodent species and brain regions studied, or induced by IH paradigms, can challenge interpretation of the studies. Hence, we conducted a systematic review and meta-analysis to evaluate the impact of IH on rodent brain oxidative stress, inflammation, apoptosis and the expression of brain-derived neurotrophic factor (BDNF) and hypoxia-inducible factor 1 (HIF-1).
View Article and Find Full Text PDFBackground: While numerous antimicrobial stewardship programs aim to decrease inappropriate antibiotic prescriptions, evidence of their positive impact is needed to optimize future interventions.
Objective: This study aimed to evaluate 2 multifaceted antibiotic stewardship interventions for inappropriate systemic antibiotic prescription in primary care.
Methods: An open-label, cluster-randomized controlled trial of 2501 general practitioners (GPs) working in western France was conducted from July 2019 to January 2021.
Article Synopsis
- Legumes form partnerships with AM fungi and rhizobia to enhance their nutrient intake, using specific structures in their roots for effective exchange.
- The research focuses on Medicago truncatula, revealing that MtAnn1 protein plays a critical role in the formation of cytoplasmic cell bridges for rhizobia entry, influencing calcium signaling and infection success.
- MtAnn1 not only contributes to rhizobia symbiosis but is also essential for arbuscule development in AM fungi, indicating its importance in ancient calcium-regulatory mechanisms for symbiotic infections.
Difficult to Treat Depression: Focus on Approach, Algorithms, and Access.
J Clin Psychiatry
November 2024
Article Synopsis
- The pandemic intensified awareness of depression's impact throughout life, prompting healthcare systems and advocates to prioritize prevention and treatment.
- Efforts continue to tackle the challenge of treating adult patients with difficult-to-treat depression who don’t respond to standard medications, while the psychiatric workforce faces limitations.
- The University of Arizona hosted the Southwest Forum on Difficult to Treat Depression in July 2024, bringing together experts to discuss innovative treatment methods, effective care algorithms, and improving access to depression care.
Effects of preoperative treatment on healthcare utilization and return to work for anterior cruciate ligament injuries: a real-world study using the French healthcare database.
Phys Sportsmed
December 2024
Objective: To compare healthcare use and the number of days of sickness benefits between people with anterior cruciate ligament (ACL) injury who received physiotherapy before and after ACL reconstruction (ACLR) and those who received physiotherapy after ACLR only. Secondary aim: to measure the association between the volume of preoperative healthcare and post-ACLR recovery.
Methods: Each individual's care pathway was extracted from a section of the French National Health Data System (SNDS) database (province: Pays de La Loire).