Pharmacokinetics of naftidrofuryl in patients with renal impairment.

Naftidrofuryl (CAS 31329-57-4) is used, mainly in elderly patients, in the treatment of various vascular disorders. The aim of this study was to evaluate and compare the pharmacokinetics of naftidrofuryl after single oral administration of a 200 mg naftidrofuryl tablet (Praxilene) in caucasian male and female subjects with renal impairment versus healthy volunteers. This prospective and open study was conducted in three parallel groups: Group A = healthy subjects with a Cl(CR) > 80 ml/min, Group B = uraemic patients with a 20 < or = Cl(CR) < 40 ml/min, Group C = uraemic patients with a Cl(CR) < 20 ml/min.

[The flavonoids effect against vinblastine, cyclophosphamide and paracetamol toxicity by inhibition of lipid-peroxydation and increasing liver glutathione concentration].

The paracetamol and cyclophosphamid are metabolized in the liver by the cytochrome P450. The formed reactive intermediates are responsible of a hepatocyte depletion of the glutathion and a lipoperoxydation. the vinblastine is also a chemotherapeutic agent hepatotoxic and hematotoxic.

[Is it possible to reduce the incidence of aminoglycoside-induced nephrotoxicity?].

The incidence of nephrotoxicity due to aminoglycosides should be sharply reduced. The indications for prescribing these antibiotics should be limited to infectious disorders induced by aerobic Gram-negative bacteria and by some Gram-positive bacteria requiring treatment in specialized hospital units using an association of aminoglycosides and another antibiotic. Daily doses should not exceed those indicated by the manufacturer, and the length of treatment should be as short as possible, with a relay to other antibiotics that are not or are less nephrotoxic.

[A priority mission: prevention, early detection, identification of risk factors of progression of chronic renal insufficiency].

The prevalence of chronic renal failure is continuously increasing. The reasons are the lengthening life expectancy of the general population, the increasing age of the patient population benefitting from renal replacement therapy and the growing number of vascular and diabetic nephropathies leading to end-stage renal disease. The financial burden of treating renal failure is considerable, estimated at nearly 2 percent of the national health budget.

[Massive poisoning by African bee stings].

Background: Bee stings can cause severe toxic effects when envenomation is massive.

Case Report: While touring in Casamance (Southern Senegal) a white male was severely stung by a swarm of African bees. The massive envenomation caused rhabdomyolysis, hemolysis and acute renal failure.