Publications by authors named "J P Dzoyem"
Enteric fever is a significant health problem in developing countries caused by serovars Typhi and Paratyphi. Unfortunately, the burden of the disease remains high not only because of the complications related to the disease but also, especially, because of the spread of the strains of resistant to antibiotics. The aim of the present study was to evaluate the antibiotic resistance patterns of Typhi and Paratyphi clinical isolates as well as the risk factors associated with infection.
View Article and Find Full Text PDFAmong the Candida species commonly involved in superficial and more significant life-threatening infections, C. krusei exhibits the most worrisome resistance profile to antifungals. This study aimed to analyse the population structure using multilocus sequence typing (MLST), and to evaluate the antifungal susceptibility profile of C.
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- The study focused on the combination of quinic acid and kanamycin in targeting biofilms formed by methicillin-resistant Staphylococcus aureus (MRSA), which are known to complicate treatment efforts.
- It utilized various methods, including broth microdilution and scanning electron microscopy, to evaluate the antibacterial and antibiofilm activities of the drug combination.
- The results indicated that the combination was effective in eradicating MRSA biofilms without harming human kidney cells, suggesting a promising new strategy for treating MRSA-related infections.
Medicinal plants are rich sources of bioactive compounds with diverse pharmacological properties, including antimicrobial activities. This study aimed to assess the antibiofilm potential of methanol and ethanol extracts from nine selected medicinal plants, as well as their synergistic effects with doxycycline against strains. Standard procedures were employed to determine the phytochemical composition, total phenolic, and flavonoid contents of the extracts.
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- - A new saponin called diosgeninoside and a new fatty acid named betacic acid were discovered alongside six known compounds in a methanolic extract.
- - The chemical structures of these compounds were determined using 1D and 2D NMR spectrometry and other methods.
- - Both the methanolic extract and one of its fractions demonstrated moderate antibacterial activity against specific bacteria, with minimum inhibitory concentrations (MIC) measured at 128 µg/mL and 64 µg/mL for certain compounds.