Publications by authors named "J P Devillers"

Article Synopsis
  • Researchers developed a SAR (Structure-Activity Relationship) model to help identify new mosquito repellents from a dataset of 2,171 molecules, using detailed molecular descriptors as inputs.
  • The best-performing model, a three-layer perceptron with a structure of 20/6/2, achieved 94% accuracy on training data and 89% on test data.
  • This model was further utilized to predict the repellent effectiveness of new molecules, with two of them successfully tested in live organisms.
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Mosquito-borne diseases such as malaria, dengue, or chikungunya have been re-emerging all over the world, including in Europe. Managing resistance to public health pesticides in mosquitoes is essential and requires global, integrated, and coordinated actions and strong engagement of decision-makers, scientists, and public health operators. In this context, the present work aims at proposing an integrated plan of resistance surveillance in France and in the French Overseas territories in order to provide graduated and appropriate responses according to the situation.

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Spraying repellents on clothing limits toxicity and allergy problems that can occur when the repellents are directly applied to skin. This also allows the use of higher doses to ensure longer lasting effects. As the number of repellents available on the market is limited, it is necessary to propose new ones, especially by using in silico methods that reduce costs and time.

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Use of protective clothing is a simple and efficient way to reduce the contacts with mosquitoes and consequently the probability of transmission of diseases spread by them. This mechanical barrier can be enhanced by the application of repellents. Unfortunately the number of available repellents is limited.

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Pyriproxyfen is a juvenile hormone mimic used extensively worldwide to fight pests in agriculture and horticulture. It also has numerous applications as larvicide in vector control. The molecule disrupts metamorphosis and adult emergence in the target insects.

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