Publications by authors named "J P Cottier"
Aims: FGFR-fused central nervous system (CNS) tumours are rare and are usually within the glioneuronal and neuronal tumours or the paediatric-type diffuse low-grade glioma spectrum. Among this spectrum, FGFR2 fusion has been documented in tumours classified by DNA-methylation profiling as polymorphous low-grade neuroepithelial tumours of the young (PLNTY), a recently described tumour type. However, FGFR2 fusions have also been reported in glioneuronal tumours, highlighting the overlapping diagnostic criteria and challenges.
View Article and Find Full Text PDFArticle Synopsis
- Anatomical 3D-printed nasal casts are important for studying how drugs are delivered inside the nose and provide unique preclinical data not available from animal studies.
- The study analyzed CT scans from 98 patients, revealing anatomical differences in the nasal cavity and identifying three distinct nasal geometry groups, leading to the creation of representative 3D models.
- The research demonstrated that these anatomical variations significantly impact how well different medical devices deliver drugs, especially with nasal sprays and nebulizers, highlighting the need for diverse models to assess drug effectiveness in different populations.
Article Synopsis
- Intracerebral hemorrhage (ICH) is a serious condition that requires effective imaging for diagnosis, yet there is a lack of standardization in imaging protocols during the acute phase.
- A study reviewed over 18,000 patients suspected of acute stroke to assess imaging methods, finding that CT scans were the most commonly used, followed by vascular imaging in a majority of cases.
- The research revealed that 8.2% of ICH cases had secondary causes identified, emphasizing the need for improved and standardized imaging approaches to ensure quicker detection and treatment of vascular issues.