Publications by authors named "J P Corradi"
Article Synopsis
- Estrogen receptor (ER) alpha is a key factor in ER+/HER2- breast cancer, and combining current therapies with new drugs is essential due to resistance issues like ESR1 mutations.
- Vepdegestrant (ARV-471) is a new drug that efficiently degrades both wild-type and mutant ER, showing significant tumor growth inhibition in various breast cancer models, outperforming the standard treatment fulvestrant.
- The study suggests that vepdegestrant could be a more effective treatment option for patients with ER+/HER2- breast cancer, especially when combined with other therapies like CDK4/6, mTOR, or PI3K inhibitors.
Article Synopsis
- Targeted protein degradation (TPD) is highlighted as a new therapeutic strategy using PROTAC technology to selectively degrade proteins in cells.
- Researchers discovered small-molecule ligands that specifically target the E3 ligase KLHDC2, expanding the options available for TPD.
- The study reveals how the KLHDC2 E3 ligase forms a dynamic tetrameric structure, which can be influenced by the interaction with substrates and ligands, enhancing our understanding of its functioning and potential applications.
Pancreatic beta cells secrete insulin in response to plasma glucose. The ATP-sensitive potassium channel (K ) links glucose metabolism to islet electrical activity in these cells by responding to increased cytosolic [ATP]/[ADP]. It was recently proposed that pyruvate kinase (PK) in close proximity to beta cell K locally produces the ATP that inhibits K activity.
View Article and Find Full Text PDFNicotinic acetylcholine receptors (nAChRs) are involved in a great range of physiological and pathological conditions. Since they are transmembrane proteins, they interact strongly with the lipids surrounding them. Thus, the plasma membrane composition and heterogeneity play an essential role for the correct nAChR function, on the one hand, and the nAChR influences its immediate lipid environment, on the other hand.
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