Publications by authors named "J P Cline"
Article Synopsis
- Research shows that breast tissue has a unique, changeable microbiome that can be influenced by endocrine-targeting therapies such as tamoxifen.
- Tamoxifen treatment was found to change the diversity of the breast microbiome and increase levels of certain beneficial bacteria, like Lactobacillus, in both mice and primates.
- Probiotic bacteria injections in lab mice not only reduced tumor formation but also affected gene expression related to metabolism, suggesting a link between breast microbiome changes and lower risk of estrogen receptor-positive breast cancer.
How did we let the mouth get separated from the rest of the body? And more importantly, how do we put oral health back into overall health? This issue of the NCMJ highlights recent efforts to develop strategies to create an accessible, sustainable, and equitable care delivery system in North Carolina.
View Article and Find Full Text PDFNational security concerns regarding radiological incidents, accidental or intentional in nature, have increased substantially over the past few years. A primary area of intense planning is the assessment of exposed individuals and timely medical management. However, exposed individuals who receive survivable radiation doses may develop delayed effects of acute radiation exposure many months or years later.
View Article and Find Full Text PDFEpidemiological and observational studies suggest that vitamin D has potential for the chemoprevention of ovarian cancer. The anticancer effect of vitamin D in the fallopian tube epithelium (FTE), which is now thought to harbor the precursor cells for high grade ovarian cancer, is not known. The purpose of this study was to investigate whether vitamin D can inhibit carcinogenesis in the mogp-TAg fallopian tube (FT) ovarian cancer mouse model and examine underlying mechanisms.
View Article and Find Full Text PDFArticle Synopsis
- Exposure to total body irradiation (TBI) in adult rhesus macaques shows that it leads to slight declines in cortical bone microstructure, like reduced thickness and area, but does not significantly affect material composition or mechanical properties compared to non-irradiated controls.
- While TBI was administered after peak bone mass was achieved, the study suggests that skeletons of long-term survivors might maintain their mechanical integrity even with some radiation-induced structural changes.
- Additionally, aging impacts the mechanical behavior of bones, particularly reducing toughness to fracture, indicating further research is needed to understand how radiation may cause bone fragility in both mature and immature bones for better patient care.