HSP27/IL-6 axis promotes OSCC chemoresistance, invasion and migration by orchestrating macrophages via a positive feedback loop.

Novel strategies to disrupt tumor progression have emerged from studying the interactions between tumor cells and tumor-associated macrophages (TAMs). However, the molecular mechanisms of interactions between tumor cells and TAMs underlying oral squamous cell carcinoma (OSCC) progression have not been fully elucidated. This study explored the molecular mechanism of the HSP27/IL-6 axis in OSCC chemoresistance, invasion, and migration.

Research Progress of SGLT2 Inhibitors in Cancer Treatment.

Sodium glucose co-transporter 2 (SGLT2) inhibitors represent a novel class of hypoglycemic drugs that have emerged in recent years. These inhibitors function primarily by blocking the reabsorption of glucose in the kidneys, specifically targeting the SGLT2 proteins in the proximal convoluted tubules. This inhibition results in the reduction of blood glucose levels through increased glucose excretion in the urine.

Study on the Preparation and Electrochemical Properties of LiFeMnPO Coated with Bamboo Shaving-Based Carbon.

LiFeMnPO (0 < < 1) has a high operating voltage range and theoretical energy density, but its actual capacity decreased due to its low electronic conductivity. To overcome this problem, we successfully prepared LiFeMnPO/C (LFMP/C) with a uniform carbon coating by a one-step solvothermal method using bamboo shavings as the carbon source. The results showed that heating at a reaction temperature of 180 °C for 18 h was the optimal synthesis condition to obtain LFMP/C.