Publications by authors named "J P Brouland"
Article Synopsis
- Diagnosis of primary diffuse large B-cell lymphoma of the central nervous system (PCNSL) is often difficult and delayed due to low sensitivity of standard tests like MRI, CSF cytology, and even brain biopsies.
- In three reported cases, novel CSF biomarkers, including the MYD88 L265P mutation and specific cytokine levels, helped suggest the diagnosis of PCNSL, which was later confirmed by biopsy or autopsy.
- The study highlights five key CSF biomarkers (IL-10, IL-10/IL-6 ratio, CXCL13, MYD88 mutation, and monoclonal immunoglobulin rearrangements) that can improve diagnostic accuracy for PCNSL.
Brain metastasis (BrM) is a common malignancy, predominantly originating from lung, melanoma, and breast cancers. The vasculature is a key component of the BrM tumor microenvironment with critical roles in regulating metastatic seeding and progression. However, the heterogeneity of the major BrM vascular components, namely endothelial and mural cells, is still poorly understood.
View Article and Find Full Text PDFBackground: Immune checkpoint inhibitors (ICIs) are reshaping the prognosis of many cancers, but often cause immune-related adverse events (irAEs). Among neurological irAEs, myositis is the most frequently reported. Our aim is to describe clinical and non-clinical characteristics, treatment and outcome of all irMyositis (skeletal limb-girdle and/or ocular myositis) and irMyocarditis cases in our reference center.
View Article and Find Full Text PDFArticle Synopsis
- * A study looked closely at neutrophils in tumor tissues from patients with glioma (a type of brain cancer) and brain metastasis (cancer that has spread to the brain) and compared them to those in blood.
- * The researchers found that neutrophils in brain tumors are different from those in blood; they live longer and can help tumors grow by suppressing the immune response and causing inflammation.
Background And Aim: About a third of Pituitary Neuroendocrine Tumors (PitNETs) may show aggressive behavior. Many efforts have been performed for identifying possible predictive factors to early determine the future behavior of PitNETs. Programmed cell death ligand 1 (PD-L1) expression was associated with a more aggressive biology in different solid tumors, but its role in PitNET is not well-established yet.
View Article and Find Full Text PDF