Publications by authors named "J P Boulos"
The altered response to chemotherapeutic agents predominantly stems from heightened single-point mutations within coding regions and dysregulated expression levels of genes implicated in drug resistance mechanisms. The identification of biomarkers based on mutation profiles and expression levels is pivotal for elucidating the underlying mechanisms of altered drug responses and for refining combinatorial therapeutic strategies in the field of oncology. Utilizing comprehensive bioinformatic analyses, we investigated the impact of eight mismatch repair (MMR) genes on overall survival across 23 cancer types, encompassing more than 7500 tumors, by integrating their mutation profiles.
View Article and Find Full Text PDFSelective activation of individual subtypes of muscarinic receptors is a promising way to safely alleviate a wide range of pathological conditions in the central nervous system and the periphery as well. The flexible G-protein interface of muscarinic receptors allows them to interact with several G-proteins with various efficacy, potency, and kinetics. Agonists biased to the particular G-protein mediated pathway may result in selectivity among muscarinic subtypes and, due to the non-uniform expression of individual G-protein alpha subunits, possibly achieve tissue specificity.
View Article and Find Full Text PDFNitrogen-containing molecules are used for the synthesis of polymers, surfactants, agrochemicals, and dyes. In the context of green chemistry, it is important to form such compounds from bioresource. Short-chain primary amines are of interest for the polymer industry, like 2-aminopropanol, 1-aminopropan-2-ol, and 1,2-diaminopropane.
View Article and Find Full Text PDFL., a member of the Apiaceae family, comprises 13 subspecies, with one being cultivated ( L. ssp.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the effects of plastic and microplastic compounds on human health, highlighting their presence in human blood and placenta, and focusing on their interactions with cytochrome P450 monooxygenases (CYPs), crucial for metabolism.
- - Virtual screening of over 1,000 plastic-related compounds led to the identification of three candidates that showed strong binding to CYP3A4 and demonstrated cytotoxic effects, affecting various metabolic pathways.
- - The research revealed that these compounds suppressed key biological pathways, particularly those involved in cell division and DNA replication, which were validated through cell cycle analysis and gel electrophoresis.