Publications by authors named "J P Bird"
Article Synopsis
- Safe and Sustainable by Design (SSbD) is a new regulatory approach aimed at guiding the development of chemicals and materials, recommended by the European Commission with a focus on a two-stage framework.
- The SSbD process involves setting principles for redesigning materials and assessing their safety and sustainability, but its effectiveness for advanced materials like TiCT MXenes still needs further exploration.
- Research on TiCT MXenes indicates they are safe and sustainable under the SSbD framework, but more studies are required on their long-term effects and the eco-friendly production of titanium, as well as guidance on evaluating the relevant evidence for SSbD assessments.
To understand the mechanics and kinetic properties of cytoskeletal molecular motors such as myosin, typically the motor of interest needs to be expressed and purified and then analyzed using a range of in vitro-based assays. In this chapter, we describe how to express and purify myosin using the insect cell system, how to characterize the purified protein by mass photometry and negative-stain EM to assess its quality, and how to perform in vitro assays in which fluorescently labeled myosin walks along actin tracks, including a brief description of adapting these assays for MINFLUX imaging.
View Article and Find Full Text PDFPurpose: Low intraabdominal pressure (IAP) during laparoscopy is associated with improved post-operative outcomes across a variety of surgical specialties. A prospective cohort study was undertaken to assess post-operative outcomes in patients undergoing laparoscopic colorectal surgery (LCRS) with low (8mmHg) versus conventional (15mmHg) IAP.
Methods: A prospective real-world observational study of patients undergoing LCRS in a single-centre, between June 2020 and June 2023 was performed.
Article Synopsis
- In the auditory and vestibular systems, stereocilia are specialized structures that convert sound and motion into electrical signals, with their growth involving the addition of actin filaments.
- Research focused on how stereocilia widen during development, finding that new actin filaments first incorporate at the tips before spreading along the shaft, indicating that the core structure remains stable.
- The study revealed a previously unrecognized population of short actin filaments at the tips of stereocilia, which are influenced by specific myosin motors (MYO3A/B and MYO15A) that play a crucial role in their growth and stabilization, suggesting these interactions are important for proper mechanosensory function.