Supporting follow-up care in colorectal cancer patients: first experiences with the Assessment of Burden of ColoRectal Cancer (ABCRC)-tool.

Purpose: The Assessment of Burden of ColoRectal Cancer (ABCRC)-tool is a unique tool that includes a PROM focused on health-related quality of life (HRQoL), functional outcomes and lifestyle assessment. Furthermore, it provides visualization of results and treatment advice. The tool aims to support follow-up consultations of colorectal cancer (CRC) patients.

Decades of monitoring plastic pollution in seabirds in Canada: Spatial, temporal, and methodological insights.

Plastic ingestion by seabirds is an increasing issue worldwide, yet species can vary in ingestion based on ecological and morphological differences. This provokes the ecological question of which species are better suited to monitor plastic ingestion across regions and time. In Canada, we examined plastic ingestion in sympatric northern fulmars (Fulmarus glacialis), black-legged kittiwakes (Rissa tridactyla), thick-billed murres (Uria lomvia), and black guillemots (Cepphus grylle).

Self-Consistent Many-Body Metrology.

We investigate the classical and quantum metrology of performing parameter estimation with interacting trapped bosons, which we theoretically treat by a self-consistent many-body approach of the multiconfigurational Hartree type. Focusing on a tilted double-well geometry, we compare a self-consistently determined and monitored two-mode truncation, with dynamically changing orbitals, to the conventional two-mode approach of fixed orbitals, where only Fock space coefficients evolve in time. We demonstrate that, as a consequence, various metrological quantities associated to a concrete measurement such as the classical Fisher information and the maximum likelihood estimator are deeply affected by the orbitals' change during the quantum evolution.

The Ki67 dilemma: investigating prognostic cut-offs and reproducibility for automated Ki67 scoring in breast cancer.

Purpose: Quantification of Ki67 in breast cancer is a well-established prognostic and predictive marker, but inter-laboratory variability has hampered its clinical usefulness. This study compares the prognostic value and reproducibility of Ki67 scoring using four automated, digital image analysis (DIA) methods and two manual methods.

Methods: The study cohort consisted of 367 patients diagnosed between 1990 and 2004, with hormone receptor positive, HER2 negative, lymph node negative breast cancer.

The relationship between plastic ingestion and trace element concentrations in Arctic seabirds.

Seabirds ingest contaminants linked to their prey's tissues, but also adsorbed to ingested plastic debris. To explore relationships between ingested plastics and trace elements concentrations, we analyzed 25 essential non-essential trace elements in liver tissue in relation to plastic content in the gastrointestinal tract in adults of four species of Arctic seabirds with different propensity to ingest plastic. Linear Discriminant Analysis (LDA) provided a clear separation between species based on element concentrations, but not among individuals with and without plastics.