Color Stability of Different Restorative Approaches for the Masking of Silver Diamine Fluoride after Thermal Aging.

Aim: The present study aims to evaluate the color stability of different masking modalities of silver diamine fluoride (SDF) on extracted carious teeth after thermal aging.

Methods And Results: One hundred and eight recently extracted carious permanent teeth were used. All sample teeth had SDF applied over the carious lesion.

A Retrospective Evaluation of the Prevalence of Cracked Teeth Among an Adult Population in Nevada.

Objective: To identify the distribution and characteristics of cracked teeth in a Southern Nevada population attending the dental clinics of the School of Dental Medicine, University of Nevada, Las Vegas (SDM, UNLV).

Methods: A retrospective keyword search of the clinical notes of SDM, UNLV patient charts in AxiUm™ was performed using the search terms 'crack' and 'fracture' to discern the number of patients that had clinically identifiable teeth with cracks, and which teeth (if any) had documented symptoms consistent with the cracks. The inclusion criteria for the record search were individuals ≥18 years old, seen at the dental clinic between 2010 and 2018.

Self-Management in Epilepsy Care: Untapped Opportunities.

Constant accessibility, rapid scalability, and modest costs make digital and mobile epilepsy self-management platforms an attractive alternative to resource-intensive in-person programs.

Biomechanical Forces Promote Immune Regulatory Function of Bone Marrow Mesenchymal Stromal Cells.

Mesenchymal stromal cells (MSCs) are believed to mobilize from the bone marrow in response to inflammation and injury, yet the effects of egress into the vasculature on MSC function are largely unknown. Here we show that wall shear stress (WSS) typical of fluid frictional forces present on the vascular lumen stimulates antioxidant and anti-inflammatory mediators, as well as chemokines capable of immune cell recruitment. WSS specifically promotes signaling through NFκB-COX2-prostaglandin E (PGE ) to suppress tumor necrosis factor-α (TNF-α) production by activated immune cells.

Fluid shear stress activates YAP1 to promote cancer cell motility.

Mechanical stress is pervasive in egress routes of malignancy, yet the intrinsic effects of force on tumour cells remain poorly understood. Here, we demonstrate that frictional force characteristic of flow in the lymphatics stimulates YAP1 to drive cancer cell migration; whereas intensities of fluid wall shear stress (WSS) typical of venous or arterial flow inhibit taxis. YAP1, but not TAZ, is strictly required for WSS-enhanced cell movement, as blockade of YAP1, TEAD1-4 or the YAP1-TEAD interaction reduces cellular velocity to levels observed without flow.