Continuous infusion of ropivacaïne: an optimal postoperative analgesia regimen for iliac crest bone graft in children.

Background: Postoperative analgesia of iliac crest (IC) donor site can be performed by on site infiltrations of local anesthetics (LA) or morphine. Single injections or continuous infusions of LA proved their efficacy in adults, but was not reported in children. We prospectively evaluated the interest of a continuous infusion of 0.

Population pharmacokinetics of the two enantiomers of tramadol and O-demethyl tramadol after surgery in children.

Background: Few data are available on the stereoselective pharmacokinetics of tramadol in children. The aim of this study was to develop a population pharmacokinetic model for the (+)- and (-)-enantiomers of tramadol and its O-demethyl tramadol metabolite (M1) in children.

Methods: Twenty-five children (1-8 yr) were included in this study.