Publications by authors named "J Otu"
Background: Mycobacterium tuberculosis culturing remains the gold standard for laboratory diagnosis of tuberculosis. Tuberculosis remains a great public health problem in developing countries like The Gambia, as most of the methods currently used for bacterial isolation are either time-consuming or costly.
Objective: To evaluate the Kudoh swab method in a West African setting in Gambia, with a particular focus on the method's performance when culturing Mycobacterium africanum West Africa 2 (MAF2) isolates.
In recent years Bamako has been faced with an emerging threat from multidrug resistant TB (MDR-TB). Whole genome sequence analysis was performed on a subset of 76 isolates from a total of 208 isolates recovered from tuberculosis patients in Bamako, Mali between 2006 and 2012. Among the 76 patients, 61(80.
View Article and Find Full Text PDFBackground: Mycobacterium tuberculosis drug resistance is a major challenge to the use of standardized regimens for tuberculosis (TB) therapy, especially among previously treated patients. We aimed to investigate the frequency and pattern of drug resistance among previously treated patients with smear-positive pulmonary tuberculosis at the Korle-Bu Teaching Hospital Chest Clinic, Accra.
Methods: This was a cross-sectional survey of mycobacterial isolates from previously treated patients referred to the Chest Clinic Laboratory between October 2010 and October 2013.
Background: Drug resistance surveillance is crucial for tuberculosis (TB) control. Therefore, our goal was to determine the prevalence of second-line anti-TB drug resistance among diverse primary drug-resistant complex (MTBC) isolates in Ghana.
Materials And Methods: One hundred and seventeen MTBC isolates with varying first-line drug resistance were analyzed.
Article Synopsis
- - Nigeria is facing a growing issue with multidrug-resistant tuberculosis (MDR-TB), necessitating the use of whole-genome sequencing to analyze its spread and genetic factors in patients from two hospitals in Southwest Nigeria.
- - Most tuberculosis cases analyzed belong to the Cameroon clade of the Euro-American lineage, which is spreading rapidly and is linked to both drug-sensitive and multidrug-resistant infections.
- - Five patients showed pre-XDR TB due to fluoroquinolone resistance, with mutations in the gyrA gene; genomic changes during treatment highlight the importance of understanding inter-patient transmission of resistant strains to combat MDR-TB.