Publications by authors named "J Otten"
Objective: This study investigated absorption, metabolism, and excretion of adagrasib after a single oral 600 mg dose (1 µCi [C]-adagrasib) in 7 healthy subjects and compared the metabolite profile to the profile at steady-state in 4 patients dosed at 600 mg twice daily.
Methods: Plasma, urine, and feces were collected post [C]-adagrasib administration and total radioactivity and pooled sample metabolite profiles were determined. Adagrasib pharmacokinetics were determined in plasma and urine.
Purpose: Optical tracking devices (OTDs) hold promise for enhancing patient-centered prostheses, but their efficacy remains underexplored. This clinical study aimed to comprehensively evaluate differences in static and dynamic occlusions among occlusal appliances fabricated using optical tracking, conventional tracking, and average articulator values (AAVs), providing insights into their efficacy in clinical and research-based practices.
Materials And Methods: Twelve dentate participants aged over 25 years, with Angle Class I and II occlusal relationships, were enrolled.
Article Synopsis
- Uterine fibroids present challenges for patients, especially regarding symptoms and fertility, prompting this research to compare open and laparoscopic myomectomy in terms of quality of life and pregnancy outcomes.
- The study examined 168 patients who underwent myomectomy from October 2017 to July 2023, focusing on preoperative characteristics and postoperative results concerning symptoms and pregnancy.
- Findings indicated that while both surgical methods resulted in high patient satisfaction and similar pregnancy outcomes, laparoscopic myomectomy had lower recurrence rates and cesarean section recommendations, suggesting it may be a preferable option for patients.
Purpose Of Review: Olfactory dysfunction significantly impacts quality of life that affects a majority of the patients with chronic rhinosinusitis with nasal polyps (CRSwNP). The aim of this review is to explore the impact of various treatment regimens on olfactory dysfunction in patients diagnosed with CRSwNP.
Recent Findings: Accurate assessment of olfactory dysfunction remains challenging and should incorporate both psychophysical tests and patient-reported outcomes.
Background: Dyslipidaemia in patients with diabetes contributes to the risk of atherosclerotic cardiovascular disease. We aimed to identify a dyslipidemic profile associated with both dysglycemia and subclinical coronary atherosclerosis.
Methods: Study participants (n = 5050) were classified in three groups: normoglycemia, pre-diabetes, and diabetes.