Publications by authors named "J Osterreicher"
This study evaluates the antimycobacterial potential of novel "mutual" bioactive amides, combining pyridine-4-carbohydrazide (isoniazid, INH) with various antimicrobial agents (sulphonamides, 4-aminosalicylic acid, thiosemicarbazide, diphenyl (thio)ethers) oxocarboxylic acids. The aim was to enhance activity against both drug-susceptible and multidrug-resistant (MDR) and non-tuberculous strains, while overcoming drug resistance through dual-action mechanisms. Many derivatives exhibited potent antimycobacterial activity, with minimum inhibitory concentrations (MICs) as low as ≤0.
View Article and Find Full Text PDFStandard ultrasonic thickness measurements require the sound velocity of the sample to be known and vice versa. We present a method, which we have termed combined mode local acoustic spectroscopy (CoMLAS) for simultaneously determining a plate's thickness and sound velocities without requiring such a priori knowledge. It is based on a combination of three guided wave modes sustained by a plate at discrete frequencies, which we generate and detect using laser ultrasound.
View Article and Find Full Text PDFMicrostructure analysis via electron backscatter diffraction has become an indispensable tool in materials science and engineering. In order to interpret or predict the anisotropy in crystalline materials, the texture is assessed, e.g.
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- Characterizing Zr-containing dispersoids in aluminum alloys is tough due to their size variability and uneven distribution in the material.
- This study compared small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS) with scanning electron microscopy (SEM) and transmission electron microscopy (TEM) for analyzing these dispersoids in a specific type of aluminum alloy.
- SAXS was found to be more sensitive to Zr dispersoids, while SANS can examine larger sample volumes; using both techniques together effectively distinguishes dispersoids from other phases, although SEM results diverged from others due to its resolution limits.
Purpose: To examine the p38 mitogen-activated protein kinase (p38) phosphorylation and transforming growth factor beta 1 (TGF-β1) expression in rat colon enterocytes after irradiation and their contribution to pathology of intestinal radiation disease.
Materials And Methods: Male Wistar rats were irradiated with whole body γ-radiation of 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 Gy ((60)Co, 1.