Publications by authors named "J Oscarsson"
The objective was to evaluate using unstimulated saliva in detecting and to compare the saliva and subgingival and mucosa membrane occurrence of this periodontal pathogen in patients diagnosed with advanced periodontitis. Patients with advanced forms of periodontitis ( = 220; mean age: 54.03 ± 03 years) at stage III/IV were sampled.
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- The protocol outlines a method for assessing the fitness of the oral symbiont A. aphrophilus related to its type VI secretion system (T6SS) using competition assays and metaproteomics.
- It includes guidelines for designing T6SS-specific mutants and conducting competition tests with the pathobiont A. actinomycetemcomitans in biofilm models.
- The biofilm model simulates the oral plaque ecosystem, featuring seven species, and for detailed procedures, it refers to the work of Oscarsson et al.
Oral bacteria naturally secrete extracellular vesicles (EVs), which have attracted attention for their promising biomedical applications including cancer therapeutics. However, our understanding of EV impact on tumor progression is hampered by limited in vivo models. In this study, we propose a facile in vivo platform for assessing the effect of EVs isolated from different bacterial strains on oral cancer growth and dissemination using the larval zebrafish model.
View Article and Find Full Text PDFThis paper aims to investigate the presence of and to assess potential indicators of the risk of severe form(s) of periodontitis. A descriptive cross-sectional study of 156 consecutive patients with periodontitis was conducted. Subgingival plaque samples were collected from the participants.
View Article and Find Full Text PDFObjective: The aim of this study was to investigate the impact of the sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin on tissue fatty acid (FA) uptake in the skeletal muscle, brain, small intestine, and subcutaneous and visceral adipose tissue of individuals with type 2 diabetes by using positron emission tomography (PET).
Research Design And Methods: In a 6-week randomized double-blind placebo-controlled trial, 53 patients with type 2 diabetes treated with metformin received either 10 mg dapagliflozin or placebo daily. Tissue FA uptake was quantified at baseline and end of treatment with PET and the long-chain FA analog radiotracer 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid.