Publications by authors named "J Ortaldo"
Objectives: The relative contributions of inflammatory signalling and sequential oncogenic dysregulation driving liver cancer pathogenesis remain incompletely understood. Lymphotoxin-β receptor (LTβR) signalling is critically involved in hepatitis and liver tumorigenesis. Therefore, we explored the interdependence of inflammatory lymphotoxin signalling and specific oncogenic pathways in the progression of hepatic cancer.
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- The study investigates how prenatal interactions between natural killer (NK) cells and alloantigens influence NK cell development, particularly in terms of tolerance versus immunity.
- Using a mouse model, researchers found that tolerance is achieved by removing NK cells that are reactive to alloantigens but lack corresponding inhibitory receptors.
- This tolerance mechanism is centered in the bone marrow during the final maturation of NK cells, highlighting a new understanding of how activating receptors play a critical role in developing durable NK cell tolerance.
Natural killer activity: early days, advances, and seminal observations.
Crit Rev Oncog
September 2014
This manuscript describes the early history of NK cell discovery, with emphasis on the events in the first decade of NK cell studies, 1972-1982. The authors highlight some of the earliest and most important observations that would later prove to be milestones in the study of NK cells and their activity.
View Article and Find Full Text PDFWe generated a mouse model with a 162 nt AU-rich element (ARE) region deletion in the 3' untranslated region (3'UTR) of the interferon-gamma (IFN-γ) gene that results in chronic circulating serum IFN-γ levels. Mice homozygous for the ARE deletion (ARE-Del) (-/-) present both serologic and cellular abnormalities typical of patients with systemic lupus erythematosus (SLE). ARE-Del(-/-) mice display increased numbers of pDCs in bone marrow and spleen.
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