Induced osteogenesis by chitosan (3-glycidoxypropyl)trimethoxysilane and silica based biomaterial in rabbits.

Introduction: Synthetic biomaterials obtained through tissue engineering offer an alternative to the use of autologous and heterologous grafts for the repair of bone defects of various etiologies, although the ideal material for this purpose has not yet been developed. A gel based on Chitosan (CS) ((3-glycidoxypropyl)trimethoxysilane (GPTMS), and silica have shown efficacy in experimental studies from a biomechanical and in vitro osseointegration perspective.

Objective: To demonstrate that the hybrid aerogel based on CS-GPTMS-silica is effective and safe for treating bone defects in load-bearing bone in rabbits.

Can we predict the graft diameter for autologous hamstring in anterior cruciate ligament reconstruction?

Unlabelled: To achieve in the reconstruction of the anterior cruciate ligament a graft with strength, tension and low comorbidity is fundamental. An emerging concept is that a graft diameter of less than 7mm carries a greater risk of re-rupture and instability. Consequently, different methods are being sought to predict intra-surgical size.