Publications by authors named "J Orsat"
Article Synopsis
- Researchers studied why some individuals are more prone to decompression sickness (DCS) than others by breeding rats with much higher resistance to DCS than the average rat.
- They analyzed the genetic expression differences between these resistant rats and a standard rat strain using advanced techniques to uncover important genes and their functions.
- The study found that pathways related to inflammation and other biological processes play significant roles in how DCS develops.
Decompression sickness (DCS) is a systemic syndrome that can occur after an environmental pressure reduction. Previously, we showed that the plasmatic tetrameric form of transthyretin (TTR) nearly disappeared in rats suffering DCS but not in asymptomatic ones. In this pilot study, we assessed whether the resistance to DCS could be associated with polymorphism of the gene of TTR.
View Article and Find Full Text PDF: The use of closed-circuit rebreathers (CCRs) in recreational diving is gaining interest. However, data regarding its physiological effects are still scarce. Immersion, cold water, hyperoxia, exercise or the equipment itself could challenge the cardiopulmonary system.
View Article and Find Full Text PDFIntroduction: Susceptibility to decompression sickness (DCS) is characterised by a wide inter-individual variability whose origins are still poorly understood. This hampers reliable prediction of DCS by decompression algorithms. We previously selectively bred rats with a 3-fold greater resistance to DCS than standard rats.
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