Publications by authors named "J Ormel"
Background: The general factor of psychopathology, often denoted as p, captures the common variance among a broad range of psychiatric symptoms. Specific factors are co-modeled based on subsets of closely related symptoms. This paper investigated the extent to which wide-ranging genetic, personal, and environmental etiologically relevant variables are associated with p and specific psychopathology factors.
View Article and Find Full Text PDF[More treatment but no less depression. An uncomfortable paradox].
Tijdschr Psychiatr
September 2023
Background: Treatments for depression have improved, and their availability has markedly increased since the 1980s. Mysteriously, the prevalence of depression in the general population has not decreased. This ‘treatment-prevalence paradox’ (TPP) raises fundamental questions about the diagnosis and treatment of depression.
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- This study examines the relationship between resting heart rate and cardiovascular diseases, identifying 493 genetic variants linked to this trait through a large-scale analysis of 835,465 individuals.
- It highlights the significance of higher genetically predicted resting heart rates, which are associated with an increased risk of dilated cardiomyopathy but lower risk for conditions like atrial fibrillation and ischemic strokes.
- The study also challenges previous findings on resting heart rate and all-cause mortality, suggesting earlier results may have been influenced by biases, ultimately enhancing our understanding of the biological implications of resting heart rate in cardiovascular health.
Article Synopsis
- The revised social defeat hypothesis redefines social defeat as low status, arguing that this outsider status can increase the risk of schizophrenia by affecting dopamine activity in the brain.
- The paper combines elements from both the social defeat hypothesis and the neurodevelopmental hypothesis, suggesting that neurodevelopmental impairments can contribute to low status and increase the risk of developing schizophrenia.
- It emphasizes that while many who experience low status do not develop schizophrenia, the combination of low socio-economic status, repeated humiliation, and poor dopamine regulation can heighten this risk.