Publications by authors named "J Origer"
Introduction: The Merendino (MER) procedure has been evaluated as an alternative to transthoracic esophageal resection (TER) for early stage Barrett's carcinoma. Apart from reducing morbidity and mortality, improvements concerning postoperative health-related quality of life (HRQL) have been postulated. The aim of our study was to compare HRQL between these procedures.
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- The study aimed to identify factors affecting prognosis in early adenocarcinomas of the esophagus (eACEs) treated with surgery.
- The analysis of 168 patients revealed that lymph node metastasis (N+) was the key indicator of overall survival and recurrence rates, with a stark contrast between those with and without N+ (47% vs. 5.2% recurrence).
- Findings suggest that while tumor depth is linked to lymph node involvement, there's no clear boundary between deep mucosal and submucosal infiltration, highlighting the need for thorough staging before treatment.
Background: There is an increasing trend to include patients with esophageal carcinoma invading the muscularis propria (pT2) in neoadjuvant therapy regimens. But it is unclear which patients have prognostic benefit from this strategy. The aim of this study was to assess the prognosis and prognostic factors in patients with pT2 esophageal adenocarcinoma to further optimize treatment strategies.
View Article and Find Full Text PDFBackground And Study Aim: Endoscopic ultrasound (EUS) has been regarded as the most accurate staging tool in esophageal cancer. Staging results have a strong impact on the decision as to whether a patient should undergo endoscopic treatment, surgery alone, or neoadjuvant therapy. This retrospective study was conducted to analyze the accuracy of esophageal cancer staging using EUS.
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- * In these cells, there is a significant decline in mRNA levels for xpf and xpg genes, which are crucial for DNA repair, after UV-C exposure.
- * c-Fos, part of the AP-1 transcription factor, plays a key role in promoting the expression of xpf, highlighting its importance in helping cells recover from UV-induced DNA damage.