[Surgical management in advanced cases of sympathoma].

In advanced stages of neuroblastoma, surgical management is limitedly indicated. In majority of cases (25/26 in own material) surgical procedures were performed for the sake of receiving samples for pathological examination. Surgical treatment was very rarely indicated.

[Role of chemotherapy in the treatment of Wilms' tumor in children].

In the years 1962-1976, 168 children with nephroblastoma (Wilms Tumour) were treated in the Clinical Department of Child Oncology of the Institute of Mother and Child in Warsaw. In 150 cases, independently from surgery and radiotherapy, chemotherapy was performed. Our material was divided into 5 groups: a) without chemotherapy, b) chemotherapy with different drugs, c) chemotherapy with 1 course of Actinomycine D, d) chemotherapy with several courses of Actinomycine D, e) chemotherapy according to SIOP Trial.

[Radioimmunological monitoring of the treatment of malignant neoplasms in childhood].

In 56 cases of children with tumours, the level of alpha-fetoprotein (AFP) was established with radio-immunological method. There were 15 children with neuroblastoma, 13 with ovarian tumours, 14 with sacro-coccygeal tumours, 7 with tumours of liver and 7 with tumours of testis. The level of AFP was elevated in all children with hepatoblastoma, carcinoma embryonale, and malignant teratoma.

[Value of polychemotherapy in the treatment of children with neuroblastoma].

The authors present a group of 10 children with neuroblastoma treated with multidrug chemotherapy. 5 children were treated according to VCAD protocol and 5 children according to COMP protocol. The VCAD protocol seems to be useful in less advanced stages of neuroblastoma (stage I and II after incomplete excision) as a prophylactic chemotherapy and in stage III with parallel irradiation of tumoral mass.