Development of a luminescence-based method for measuring West Nile Virus MTase activity and its application to screen for antivirals.

West Nile virus (WNV) is a flavivirus responsible for causing febrile illness and severe neurological diseases, with an increasing impact on human health around the world. However, there is still no adequate therapeutic treatment available to struggle WNV infections. Therefore, there is an urgent need to develop new techniques to accelerate the discovery of drugs against this pathogen.

Partial sensory rhizotomy in recurrent trigeminal neuralgia. Our experience and literature review.

Background And Objective: Trigeminal Neuralgia (NT) is a common pathology in Neurosurgery. It can be classified as idiopathic or secondary to other pathologies, such as Multiple Sclerosis (MS). Several surgical treatments have been described, some of them being replaced by more modern techniques.

Dual Antitubercular and Antileishmanial Profiles of Quinoxaline Di--Oxides Containing an Amino Acidic Side Chain.

We present a new category of quinoxaline di-N-oxides (QdNOs) containing amino acid side chains with dual antituberculosis and antileishmanial activity. These compounds were synthesized by combining a regioselective 2,5-piperazinedione opening and a Beirut reaction and were screened for their activity against and the promastigote and amastigote forms of representative species of the genus. Most QdNOs exhibited promising antitubercular activity with IC values ranging from 4.

The CF Group as a Synthon of the CF Unit in Palladium Chemistry.

The homoleptic trifluoromethyl-palladium(II) complex [Pd(CF)] (1) is shown to be highly active towards amines. Thus, when treated with primary amines RNH, it readily undergoes aminolysis of one of the CF ligands affording the isocyanide complexes [(CF)Pd(CNR)] (R=aryl). In this process the original CF group undergoes total defluorination.

Direct reductive amination of functionalized aldehydes with aniline derivatives of purines and 7-deazapurines.

Reductive amination plays a key role in the medicinal chemistry toolbox since it allows the mono alkylation of an amine or aniline. In this work, reductive amination of functionalized aldehydes with aniline derivatives of adenine and closely related 7-deazapurines has been successfully performed using H-cube technology so that imine formation and its reduction are performed "". The set-up procedure surmounts some of the drawbacks of "in batch" protocols by avoiding the handling of reductant reagents, long reaction times and tedious work-ups.