Publications by authors named "J Ordonana"
Impact of Genetic and Environmental Factors on Peripheral Refraction.
Transl Vis Sci Technol
October 2024
Article Synopsis
- The study investigates how genetics and the environment affect refractive errors in both monozygotic (MZ) and dizygotic (DZ) twins by examining multiple eye measurements.
- The results show that MZ twins exhibit higher genetic influence in refractive errors compared to DZ twins, particularly for midperipheral defocus, indicating a significant role of genetics in peripheral vision.
- The findings suggest that while environmental factors influence central vision, genetic components play a bigger role in peripheral vision, highlighting the need for tailored approaches in managing conditions like myopia.
Co-twin studies are an elegant and powerful design that allows controlling for the effect of confounding variables, including genetic and a range of environmental factors. There are several approaches to carry out this design. One of the methods commonly used, when contrasting continuous variables, is to calculate difference scores between members of a twin pair on two associated variables, in order to analyse the covariation of such differences.
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- Individual sensitivity to environmental exposures is influenced by genetics, showing that different genetic makeups can lead to varying reactions to the same environment.
- A large meta-analysis was conducted using data from nearly 22,000 monozygotic twins to explore genetic influences on seven psychiatric and neurodevelopmental traits.
- The study found 13 significant genetic associations related to factors like stress-reactivity, growth factors, and catecholamine uptake, highlighting the potential role of genetics in understanding environmental sensitivity.
Background: Type 2 diabetes (T2D) susceptibility is influenced by genetic and environmental factors. Previous findings suggest DNA methylation as a potential mechanism in T2D pathogenesis and progression.
Methods: We profiled DNA methylation in 248 blood samples from participants of European ancestry from 7 twin cohorts using a methylation sequencing platform targeting regulatory genomic regions encompassing 2,048,698 CpG sites.
Background: Low back pain (LBP) is more likely to occur in people with a family history of this condition, highlighting the importance of accounting for familial factors when studying the individual risk of LBP. We conducted a study of opposite-sex twin pairs investigating sex differences in LBP while accounting for (genetic and shared environmental) familial factors.
Methods: We applied a matched co-twin control design to study 795 adult opposite-sex pairs from Australia, Spain, and the United States (US).