Publications by authors named "J Ordemann"
Obesity imposes serious health risks and involves alterations in resting-state functional connectivity of brain networks involved in eating behavior. Bariatric surgery is an effective treatment, but its effects on functional connectivity are still under debate. In this pre-registered study, we aimed to determine the effects of bariatric surgery on major resting-state brain networks (reward and default mode network) in a longitudinal controlled design.
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- The gastrointestinal epithelium maintains balance through the regeneration and differentiation of cells in glands and crypts, which is regulated by the Wnt/β-catenin pathway and various signaling signals.
- Researchers created mucosoid cultures from human stomachs and tested different growth factors to identify how they contribute to the differentiation of specific cell types (foveolar, chief, and parietal cells).
- Findings indicated that epidermal growth factor plays a crucial role in determining cell fate within gastric glands and may contribute to changes seen in precancerous conditions like atrophic gastritis, leading to a better understanding of gastric tissue signaling.
Head motion during magnetic resonance imaging (MRI) induces image artifacts that affect virtually every brain measure. In parallel, cross-sectional observations indicate a correlation of head motion with age, psychiatric disease status and obesity, raising the possibility of a systematic artifact-induced bias in neuroimaging outcomes in these conditions, due to the differences in head motion. Yet, a causal link between obesity and head motion has not been tested in an experimental design.
View Article and Find Full Text PDFDietary modifications leading to weight loss have been suggested as a means to improve brain health. In morbid obesity, bariatric surgery (BARS)-including different procedures, such as vertical sleeve gastrectomy (VSG), gastric banding (GB), or Roux-en-Y gastric bypass (RYGB) surgery-is performed to induce rapid weight loss. Combining reduced food intake and malabsorption of nutrients, RYGB might be most effective, but requires life-long follow-up treatment.
View Article and Find Full Text PDFObjective: causes life-long colonisation of the gastric mucosa, leading to chronic inflammation with increased risk of gastric cancer. Research on the pathogenesis of this infection would strongly benefit from an authentic human in vitro model.
Design: Antrum-derived gastric glands from surgery specimens served to establish polarised epithelial monolayers via a transient air-liquid interface culture stage to study cross-talk with and the adjacent stroma.