Publications by authors named "J Onken"
Background: Spine surgical training faces increasing challenges due to restricted working hours and greater sub specialization. Modern simulators offer a promising approach to teaching both simple and complex spinal procedures. This study evaluated the acceptance and efficacy of spine simulator training using a lumbar herniated disc model tested by 16 neurosurgical residents (PGY-1-6), and compared 3D and 2D teaching methods.
View Article and Find Full Text PDFSynaptic mechanisms that contribute to human memory consolidation remain largely unexplored. Consolidation critically relies on sleep. During slow wave sleep, neurons exhibit characteristic membrane potential oscillations known as UP and DOWN states.
View Article and Find Full Text PDFArticle Synopsis
- This study focuses on the role of Thyroid Transcription Factor-1 (TTF-1) in lung adenocarcinoma (LUAD) brain metastases, specifically its predictive value and relationship with patient outcomes.
- Researchers analyzed data from 245 patients who had brain metastases, looking at factors like tumor volume and survival rates based on TTF-1 expression status.
- Results indicate that TTF-1 negative patients had larger tumors, higher proliferation rates, and worse survival outcomes, suggesting that TTF-1 negativity signifies a more aggressive form of the disease, warranting further study on its underlying mechanisms.
Integration of a lightweight and table-mounted robotic alignment tool with automated patient-to-image registration using robotic cone-beam CT for intracranial biopsies and stereotactic electroencephalography.
Peter Truckenmueller Anton Früh Johannes Felix Kissner Nadja Katharina Moser Martin Misch Julia Onken
Neurosurg Focus
December 2024
Article Synopsis
- Robotics in neurosurgery is increasingly used, particularly with the incorporation of intraoperative imaging for precise patient registration in a new lightweight, table-mounted robotic system designed for cranial biopsies and sEEG procedures.
- The study evaluated 26 patients using the Cirq system for stereotactic biopsy or sEEG from January 2023 to August 2024, comparing results with data from the frameless VarioGuide system, specifically looking at entry errors, target errors, and vector deviation of electrodes.
- Results indicated that Cirq-assisted procedures had a mean surgical time of about 117 minutes for biopsies and 269 minutes for sEEG, revealing differences in efficiency compared to VarioGuide, where the comparable
Article Synopsis
- About one third of adults with high-grade glioma experience common mental disorders, similar to general cancer patients, with a rate of 31% identified in the study.
- Factors increasing the risk of psychiatric issues in these patients include being younger than 50, living alone, having stable disease, lower income, fatigue, and impaired cognitive function.
- There were no significant differences in psychiatric comorbidity based on gender, tumor type, or time since diagnosis, emphasizing the need for clinicians to monitor mental health closely in vulnerable patients.