Publications by authors named "J Odeberg"
Article Synopsis
- The thrombin generation assay (TGA) measures how well plasma can produce thrombin, which helps assess an individual's blood clotting ability.
- The study sought to find new biological factors affecting thrombin generation by analyzing data from 770 venous thrombosis patients and validating findings in 536 healthy individuals.
- Results showed that complement proteins C5 and C9 were significantly linked to thrombin generation, with C9 having a notable impact when tested in the lab, suggesting these proteins could influence clotting, though more research is needed to clarify their roles.
Background: The identification of cell type-specific genes and their modification under different conditions is central to our understanding of human health and disease. The stomach, a hollow organ in the upper gastrointestinal tract, provides an acidic environment that contributes to microbial defence and facilitates the activity of secreted digestive enzymes to process food and nutrients into chyme. In contrast to other sections of the gastrointestinal tract, detailed descriptions of cell type gene enrichment profiles in the stomach are absent from the major single-cell sequencing-based atlases.
View Article and Find Full Text PDFThe vascular endothelium acts as a dynamic interface between blood and tissue. TNF-α, a major regulator of inflammation, induces endothelial cell (EC) transcriptional changes, the overall response dynamics of which have not been fully elucidated. In the present study, we conducted an extended time-course analysis of the human EC response to TNF, from 30 min to 72 h.
View Article and Find Full Text PDFBackground: Intraplaque hemorrhage (IPH) is a hallmark of atherosclerotic plaque instability. Biliverdin reductase B (BLVRB) is enriched in plasma and plaques from patients with symptomatic carotid atherosclerosis and functionally associated with IPH.
Objective: We explored the biomarker potential of plasma BLVRB through (1) its correlation with IPH in carotid plaques assessed by magnetic resonance imaging (MRI), and with recurrent ischemic stroke, and (2) its use for monitoring pharmacotherapy targeting IPH in a preclinical setting.