Implementation of beaker CP for flow cytometry: Workflow optimization and integration at Stanford Health Care.

Implementing a new laboratory information system (LIS) presents an opportunity to improve operational efficiency and streamline reporting by refining workflows by utilizing LIS functionality. Flow cytometry laboratories face unique challenges because the specimen and test results may be categorized under clinical pathology (CP), anatomic pathology (AP), or both. We describe the design and implementation of reporting flow cytometry results within the Epic Beaker CP module, its interface with the Epic Beaker AP module, and integrated reporting for AP/CP cases at an academic institution.

The Impact of an Automation System Built with Jenkins on the Efficiency of Container-Based System Deployment.

This paper evaluated deployment efficiency by comparing manual deployment with automated deployment through a CI/CD pipeline using Jenkins. This study involved moving from a manual deployment process to an automated system using Jenkins and experimenting with both deployment methods in a real-world environment. The results showed that the automated deployment system significantly reduced the deployment time compared to manual deployment and significantly reduced the error rate.

Quantification of the median fluorescence intensity of CD3 and CD4 in mycosis fungoides/Sezary syndrome versus non-neoplastic control cases in peripheral blood.

Peripheral blood involvement by MF/SS has significant implications for prognosis and treatment. Flow cytometry is commonly used to assess MF/SS by analyzing the ratio of CD26- and/or CD7-CD4 + T cells and assessment of immunophenotypic abnormalities. However, distinguishing normal from abnormal cells is not always easy.

CD22-directed CAR T-cell therapy for large B-cell lymphomas progressing after CD19-directed CAR T-cell therapy: a dose-finding phase 1 study.

Background: Outcomes are poor for patients with large B-cell lymphoma who relapse after CD19-directed chimeric antigen receptor (CAR) T-cell therapy (CAR19). CD22 is a nearly universally expressed B-cell surface antigen and the efficacy of a CD22-directed CAR T-cell therapy (CAR22) in large B-cell lymphoma is unknown, which was what we aimed to examine in this study.

Methods: In this single centre, open-label, dose-escalation phase 1 trial, we intravenously administered CAR22 at two dose levels (1 million and 3 million CAR22-positive T cells per kg of bodyweight) to adult patients (aged ≥18 years) who relapsed after CAR19 or had CD19-negative large B-cell lymphoma.

Assessment of Epidemiology and Clinical Profile of Psoriatic Arthritis Patients in India.

Background: Psoriasis is an inflammatory skin disease associated with significant comorbidity. However, the characteristics of patients with psoriasis are not well documented in India, and a more detailed understanding is needed to delineate the epidemiologic profile at the regional level for better management of psoriasis. Herein, we reported the clinical profile and demographic pattern of psoriasis to further understand its burden in the Indian setting.