Publications by authors named "J O TURNER"
Tertiary lymphoid structures play important roles in autoimmune and non-autoimmune conditions. While many of the molecular mechanisms involved in tertiary lymphoid structure formation have been identified, the cellular sources and temporal and spatial relationship remain unknown. Here we use combine single-cell RNA-sequencing, spatial transcriptomics and proteomics of minor salivary glands of patients with Sjogren's disease and Sicca Syndrome, with ex-vivo functional studies to construct a cellular and spatial map of key components involved in the formation and function of tertiary lymphoid structures.
View Article and Find Full Text PDFThis commentary adds elements of analysis from the new evolutionary sociology that might help to support the mythologic hypothesis. It discusses the likelihood of a more generalized processer rather than exactly evolved psychological mechanisms, the consequences of bottlenecks, and the importance of utilizing molecular, fossil, and primate data in the authors' research program.
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- B cells can be engineered to produce therapies for genetic disorders, metabolic diseases, and cancer.
- A method was developed to collect, expand, differentiate, and track B cells from non-human primates (NHPs) using radioactively labeled imaging techniques.
- The study showed that infused B cells successfully targeted the bone marrow, spleen, and liver without serious side effects, indicating the potential for repeated treatments and the viability of NHPs as a model for human B cell medicine research.
Background: As the number of medications increases, the appropriateness of polypharmacy may become questionable due to the heightened risk of medication-related harm.
Objectives: (1) To investigate the relationship between the number of current medications used by older adults and three indicators of potentially inappropriate polypharmacy: (a) the mean number of potentially inappropriate medications (PIMs), (b) the average count of drug-drug interactions, and (c) the anticholinergic burden; (2) To characterize the population-based burden of potentially inappropriate polypharmacy by calculating the proportion of individuals with these indicators.
Design: We conducted a population-based observational study using the Quebec Integrated Chronic Disease Surveillance System.
Background: The "loss of control" over drug consumption, present in opioid use disorder (OUD) and known as escalation of intake, is well-established in preclinical rodent models. However, little is known about how antecedent behavioral characteristics, such as valuation of hedonic reinforcers prior to drug use, may impact the trajectory of fentanyl intake over time. Moreover, it is unclear if distinct escalation phenotypes may be driven by genetic markers predictive of OUD susceptibility.
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