Publications by authors named "J O Sartori"
Protein dynamics is essential for various biological processes, influencing functions such as enzyme activity, molecular recognition, and signal transduction. However, traditional protein engineering methods often focus on static structures, lacking tools to precisely manipulate dynamic behaviors. Here, we developed Mutational Energy Landscape Trap (MELT), a novel method designed to control protein dynamics by combining Normal Mode Analysis (NMA) and mutagenesis.
View Article and Find Full Text PDFArticle Synopsis
- Heat stress in poultry affects their ability to manage body temperature, but pequi oil's antioxidant properties may help alleviate these effects.
- This study examined the impact of pequi oil on laying hens under heat stress by analyzing plasma proteins after feeding two different diets over 84 days.
- Key proteins linked to inflammation, immune response, and heat adaptation were found to be enhanced in hens fed with pequi oil, suggesting it could improve resilience to heat stress and boost egg production.
Objective: Coordination to get everyone in the room at the same time for family-centered rounds (FCR) is challenging. The objective of this study was to determine if using a virtual queue that notifies nurses and families in real time when to expect the rounding team could impact their presence on rounds.
Methods: We observed rounds on two neonatal intensive care unit (NICU) teams for 6 weeks before and after implementation of a novel rounding software, Q-rounds, that shares real-time updates on when the team will arrive and allows families to répondez s'il vous plaît (RSVP) to join remotely when they cannot be there in person.
Context There is mounting evidence implicating kisspeptin signalling in placental development and function. Aims This study aimed to elucidate kisspeptin's role in trophoblast invasion and migration using three experimental models. Methods First, we examined the mouse fetus and placenta in a kisspeptin receptor (Kiss1r) knockout (KO) model.
View Article and Find Full Text PDFIntroduction: Autologous blood products like Platelet Rich Plasma (PRP) and Leukocyte and Platelets Rich Fibrin (L-PRF) have been used for many years across many types of skin ulcers. However, the effectiveness of autologous blood products on wound healing is not well established.
Methods: We evaluated the 'second generation' autologous product- Leukocyte and Platelet- Rich Fibrin (L-PRF).