Publications by authors named "J O Reagan"

Importance: Although sharing care with local oncologists after allogeneic hematopoietic cell transplantation (HCT) has been proposed for patients living far from HCT centers, it is not known whether a shared strategy is safe or improves patient quality of life (QOL).

Objective: To determine the efficacy and safety of sharing follow-up care after HCT between the HCT specialty center and local oncologists.

Design, Setting, And Participants: This was a multicenter collaborative randomized clinical trial of patients undergoing HCT at Dana-Farber Cancer Institute (DFCI)-a high volume HCT center in Boston (Massachusetts)-and 8 local oncology practices.

View Article and Find Full Text PDF

This study uses an oceanic energy budget to estimate the ocean heat transport convergence in the North Atlantic during 2005-2018. The horizontal convergence of the ocean heat transport is estimated using ocean heat content tendency primarily derived from satellite altimetry combined with space gravimetry. The net surface energy fluxes are inferred from mass-corrected divergence of atmospheric energy transport and tendency of the ECMWF ERA5 reanalysis combined with top-of-the-atmosphere radiative fluxes from the clouds and the Earth's radiant energy system project.

View Article and Find Full Text PDF
Article Synopsis
  • * NPM1 mutations are stable and unique to AML, making them effective targets for monitoring measurable residual disease (MRD) during treatment, which can help inform decisions about stem cell transplantation in high-risk patients.
  • * The review assesses the importance of MRD monitoring for predicting treatment outcomes and refining risk levels in NPM1 mutated AML, including how pre-transplant MRD positivity and conditioning intensity can impact post-transplant results.
View Article and Find Full Text PDF