Publications by authors named "J O Peixoto"
Coffee pulp, a by-product of wet coffee processing, shows significant potential in the food and health domains, but its real applications remain underexplored. This work investigated the chemical composition and bioactive properties of coffee pulp from São Miguel Island (Azores, Portugal). The studied coffee pulp exhibited high fiber content (52% dw), mostly insoluble; notable mineral levels (10.
View Article and Find Full Text PDFExploring the binomial BALB/c-Leishmania (Viannia) braziliensis model to assess the in vivo performance of Thor strain subpopulations.
Exp Parasitol
December 2024
Article Synopsis
- Leishmania (Viannia) braziliensis causes various types of leishmaniasis, and the study investigates how different subpopulations (Thor03, Thor10, Thor22) affect disease progression in BALB/c mice.
- The research found that after three weeks of infection, Thor03 and Thor10 led to larger lesions and influenced immune response markers, showing lower IL-12 and TNF levels, while Thor10 had the highest IL-10 levels.
- The study concluded that these subpopulations might lead to mild footpad lesions but can persist in lymph nodes, highlighting differences in infection patterns and immune responses among the subpopulations.
The biotechnological industry faces a crucial demand for novel bioactive compounds, particularly antimicrobial agents, to address the rising challenge of bacterial resistance to current available antibiotics. Traditional strategies for cultivating naturally occurring microorganisms often limit the discovery of novel antimicrobial producers. This study presents a protocol for targeted selection of bacterial strains using the supernatant of , which produces abundant signal molecules and antimicrobial peptides.
View Article and Find Full Text PDFArticle Synopsis
- - A new bacterial strain, identified as Comamonas sp., has been isolated from the Brazilian Cerrado biome and is classified as a novel species within the Comamonas genus, proposed to be named Comamonas brasiliensis nov.
- - Genetic analyses, including dDDH and ANI, suggested that this strain has a close relationship with Comamonas testosteroni but is distinct enough to be considered a separate species.
- - The strain is characterized as a Gram-negative, non-spore-forming, motile bacterium, with optimal growth conditions at 30°C and a pH range of 5-8, along with unique fatty acid profiles related to its metabolism.
This perspective presents and supports arguments for a new formulation of epoxy-α-lapachone loaded microemulsion (ELAP-ME), a nanosystem, as a prototype drug for the treatment of leishmaniasis. The benefits of ELAP as a multitarget compound, with properties that affect key physiological pathways of Leishmania spp. are discussed.
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