Multidimensional Risk Factors for Heart Failure in Hispanic Adults: Findings from the All of Us Research Program.

Heart failure (HF) is a leading cause of morbidity and mortality in the U.S affecting approximately 6.7 million adults.

Phosphorylation of an RNA-Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging.

The metazoan lifespan is determined in part by a complex signaling network that regulates energy metabolism and stress responses. Key signaling hubs in this network include insulin/IGF-1, AMPK, mTOR, and sirtuins. The Hippo/Mammalian Ste20-like Kinase1 (MST1) pathway has been reported to maintain lifespan in Caenorhabditis elegans, but its role has not been studied in higher metazoans.

Daily or Nondaily Vaping and Smoking Cessation Among Smokers.

Importance: An important public health goal is to increase tobacco cessation, but there is limited research on associations of vaping with tobacco cessation.

Objective: To estimate the association of vaping with long-term tobacco cessation among US cigarette smokers who used electronic nicotine delivery systems (ENDS; ie, e-cigarettes) in 2017.

Design, Setting, And Participants: This cohort study used a nationally representative sample of US cigarette smokers from the Population Assessment of Tobacco and Health cohort at wave 4 (2017) with follow-up at wave 6 (2021).

Proteomic Characterization of Cardioprotective Human Acellular Amniotic Fluid.

Amniotic fluid-derived products are a promising resource for cell therapy and tissue engineering due to their anti-inflammatory, angiogenic, and antifibrotic properties. Human amniotic fluid (hAF) has been used in medical applications such as wound healing, skin disorders, and ophthalmic conditions. Recently, we demonstrated that hAF is an effective treatment for myocardial ischemia-reperfusion injury in adult rats.