Publications by authors named "J O Olubodun"
Aims: The influence of ageing on the pharmacokinetics of zolpidem, an extensively prescribed hypnotic medication, was evaluated in healthy human volunteers.
Methods: A series of 16 elderly (age: 61-85 years) and 24 young (age: 22-42 years) volunteers received single 5 mg oral doses of zolpidem tartrate. Serum zolpidem concentrations were determined by HPLC with fluorescence detection in samples drawn during 8 h after dosage.
Sixteen normal healthy female volunteers, ages 22 to 42 years, participated in this study to determine the pharmacokinetic characteristics of zolpidem and the influence of oral contraceptives and smoking. Five of the volunteers were cigarette smokers, and 8 were on oral contraceptive preparations (OCP). All subjects received a 5 mg oral dose of zolpidem tartrate, followed by multiple blood samples that were assayed by HPLC with fluorescence detection.
View Article and Find Full Text PDFRenal effects of amlodipine in normotensive renal transplant recipients.
Nephrol Dial Transplant
February 1999
Renal effects of amlodipine in normotensive renal transplant recipients. The use of cyclosporin A (CsA) has improved the success of renal transplantation, but is associated with hypertension and significant renal toxicity. Previous reports suggest that calcium channel blockers may be useful in opposing the adverse effects of CsA.
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- Cyclosporin A (CsA) treatment can improve kidney transplant survival but may cause issues like renal vasoconstriction and hypertension, leading to a study comparing the effects of amlodipine and nifedipine on renal function and blood pressure in these patients.
- The study involved 27 hypertensive renal transplant recipients who underwent a crossover trial, receiving either amlodipine or nifedipine for 8 weeks each while on stable CsA doses.
- Results indicated both drugs similarly lowered systolic blood pressure, but amlodipine was more effective at reducing diastolic pressure; overall, amlodipine showed trends towards better renal function improvements without negative effects on graft function.
Hypertension is quite common in Africa and recent reports suggest that its prevalence might be rising with many patients not receiving treatment. It appears the majority of those receiving medical attention present at the stage of severe complications. The issue of management appears quite complex as a result of several militating factors, including ignorance of the implications of hypertension, uneven economic resources and physicians, as well as governmental factors.
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