Basic Science and Pathogenesis.

Background: SORL1 encodes the retromer-associated receptor SORLA that functions in endosomal recycling. Rare variants in SORL1 have been associated with Alzheimer's disease (AD) and rare pathogenic variants are estimated to occur in up to 2.75% of early onset AD patients and in 1.

Restructuring a Complex Genetic Function on Episomal Vectors in .

Genetic functions have evolved over long timescales and can be encoded by multiple genes dispersed in different locations in genomes, and although contemporary molecular biology enables control over single genes, more complex genetic functions remain challenging. Here, we study the restructuring and mobilization of a complex genetic function encoded by 10 genes, originally expressed from four operons and two loci on the genome. We observe subtle phenotypic differences and reduced fitness when expressed from episomal DNA and demonstrate that mutations in the transcriptional machinery are necessary for successful implementation in different bacteria.

How could 20-minute neighbourhoods impact health and health inequalities? A policy scoping review.

Background: 'Twenty-minute neighbourhoods' (or variations, such as 15-minute cities) are receiving increasing policy attention with anticipated impacts on population health (inequalities) outcomes alongside sustainability improvements. Yet, factors contributing to possible health impacts are not well understood. This scoping review aimed to identify proposed and evidenced pathways to health (inequality) outcomes from international policy plans.

Coming to terms with climate change: a glossary for climate change impacts on mental health and well-being.

Climate change is a major threat to global health. Its effects on physical health are increasingly recognised, but mental health impacts have received less attention. The mental health effects of climate change can be direct (resulting from personal exposure to acute and chronic climatic changes), indirect (via the impact on various socioeconomic, political and environmental determinants of mental health) and overarching (via knowledge, education and awareness of climate change).

Exploring young people's views of their local area related to the 20-minute neighbourhood policy: a national cross-sectional study.

This study aimed to examine how young people subjectively perceive their local neighbourhoods and compare these perceptions with objective data regarding access to amenities aligned with features of the 20-minute neighbourhood (20MN) policy. Objective data (n:287 aged 12-18 years) were gathered through an online adaptation of the Place Standard Tool for Young People in Scotland. Subjective data concerning access to ten amenities in line with the 20MN concept, along with crime statistics, area-level deprivation and urbanicity were spatially linked.