Attentive graph neural network models for the prediction of blood brain barrier permeability.

The blood brain barrier's (BBB) unique endothelial cells and tight junctions selectively regulate passage of molecules to the central nervous system (CNS) to prevent pathogen entry and maintain neural homeostasis. Various neurological conditions and neurodegenerative diseases benefit from small molecules capable of BBB penetration (BBBP) to elicit a therapeutic effect. Predicting BBBP often involves assessment of molecular properties such as lipophilicity (log ) and polar surface area (PSA) using the CNS multiparameter optimization (MPO) method.

Therapeutic potential of twenty-first century music for cancer survivorship: from music and conceptual metaphor perspectives to a synergetic effect approach.

This paper examines the therapeutic potential of twenty-first century music as a means of supplementary therapeutic care for cancer survivorship. It presents a study of songs by Rihanna, Beyoncé, Adele, Coldplay, and Imagine Dragons, which combines the analysis of relevant music features and conceptual metaphors in the lyrics to examine the effect of the songs on the audience. The main aim of this study was to highlight the emotional and cognitive impact of these songs on listeners and identify their potential role in improving the psychological condition of patients with cancer who are downtrodden or reeling from the pain of surgery, chemotherapy, and side effects of treatment.

Characterizing Negative Online Reviews of Spine Surgeons.

Design: Retrospective review.

Objective: Characterize negative reviews of spine surgeons in the United States.

Summary: Physician rating websites significantly influence the selection of doctors by other patients.

Assessment of the Antimalarial Treatment Failure in Ebonyi State, Southeast Nigeria.

The fight against malaria is a continuum as the epidemic is not abating. For proper deployment of tools in the fight against malaria, an assessment of the situation is necessary. This work assessed the level of antimalarial drug treatment failure in Ebonyi State, Nigeria.

Igbo Speech Surrogacy: Preliminary Findings Based on the Oja Flute.

This research report presents analyses of recordings from the Ìgbò culture of southeastern Nigeria of an flute player, a female speaker, and a male speaker. After a prepared performance, the participants completed two tasks: (1) mapping speech to flute playing and (2) identifying phrases played on the flute. Contour analysis is applied to annotated recordings to study the mapping of speech tone and rhythm from voice to instrument in parallel utterances by the three participants (male, female, and flute).